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GLP-1 agonists facilitate rapid weight loss, averaging 15 to 25% of body weight

Side effects are often dose-dependent, so fatigue may be more pronounced at higher doses

Vasodilatory effect Studies showed that GIPR and GLP1R are present in the smooth muscle cells and endothelial arterioles and may have a cardioprotective effect due to endothelium-dependent vasodilation [105]

These symptoms can indicate conditions like gastroparesis (severe delayed gastric emptying beyond what the medication causes), bowel obstruction, or other digestive pathology that requires medical evaluation

This Review addresses the effects of bariatric surgery on glucose regulation and the potential mechanisms responsible for both the resolution of T2DM and the induction of hypoglycaemia