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Participants were randomized in a 1:1 ratio to receive once-weekly subcutaneous injections of semaglutide (2.4 mg) or a placebo

The short-acting preparation of GLP-1RA mainly reduces postprandial blood glucose by delaying gastric emptying and increasing insulin secretion (59)

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Indeed, a recent systematic review found that, despite the substantial heterogeneity across the studies included, a larger proportion of persistent GLP-1RA users achieved better glycaemic control than non-persistent users [25]

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