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Blher M, Rosenstock J, Hoefler J, et al

The key principle remains the same: never increase a dose while actively experiencing significant gastrointestinal symptoms from the current one

They can also be used to prevent and treat endocrine disorders or metabolic diseases such as polycystic ovary syndrome (PCOS), obesity, and non-alcoholic fatty liver disease (NAFLD) (135)

It is potentially dangerous to ignore

They can slow how quickly the stomach empties after eating and also influence brain pathways involved in satiety