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The most common side effects are gastrointestinal and tend to improve after the first few weeks: Nausea, vomiting, or diarrhea (most common, especially early on) Constipation or stomach discomfort Reduced appetite Less common but serious side effects include pancreatitis, gallbladder issues, and low blood sugar particularly in patients taking diabetes medications

The table shows that SGLT2is and aldosterone antagonists provide the most robust and additive reductions in albuminuria and CKD progression, with SGLT2is showing consistent benefit across all albuminuria and eGFR levels [122]

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This personalization reduces the trial-and-error phase many patients experience when starting GLP-1 therapy, potentially saving money by identifying your ideal compound faster