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There is also one interaction worth knowing rather than guessing: tirzepatide's prescribing information advises anyone on oral contraceptives to use a back-up or non-oral method for 4 weeks after starting and after each dose increase

Finally, GLP-1 receptor agonists do not seem to affect negatively the cardiovascular risk in patients with T2D, but an ultimate all-clear regarding the risk of cardiovascular events, pancreatitis, or pancreatic cancer, which may be caused by incretin-mimetic drugs, cannot be given as there is scattered evidence for these side effects

For those with good conditioning and experience and no contraindications incorporating vigorous-intensity sessions such as high-intensity interval training (HIIT) in an indoor cycling class can have additional benefits for both blood sugar control and weight loss