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Disclosure: Ryan Costello declares no relevant financial relationships with ineligible companies.: StatPearls Publishing Copyright 2023, StatPearls Publishing LLC

Immobilized Human GLP-1R, mFc Tag at 1 g/ml (100 l/well) on the plate

Watchpoints/Conclusion Research is early and inconsistent regarding the impact of diabetes and weight loss medications on bone density and an increased likelihood of repeat spinal surgeries, with implications for the safety of joint mobilizations, the prognosis of total joint replacements, and overall bone healing

Mounjaro (tirzepatide) causes constipation in approximately 67% of patients by slowing gastric emptying and increasing colonic water reabsorption

He reviewed pre-clinical data, including findings from his own research group, and discussed how these results support GLP-1 agonists as a potential new therapeutic class for OA