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Amylase, lipase, and acute pancreatitis in people with type 2 diabetes treatedwith liraglutide: results from the LEADER randomized trial

Classical examples include thalidomide and aspirin, where toxicity profiles diverged significantly between rodents and humans

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7 8 9 GLP-1RAs attain glycaemic control through mechanisms such as increasing insulin secretion induced by hyperglycaemia, inhibiting glucagon secretion during hyperglycaemia, slowing gastric emptying, preventing substantial increases in postprandial glucose, and reducing caloric intake and body weight