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Although no significant change was observed in the bone formation marker P1NP, the semaglutide group showed a significant increase in the bone resorption marker CTX and a reduction in areal BMD at both the lumbar spine and total hip

LepRb-SHP2-MAPKs The mitogen-activated protein kinases (MAPKs) are a series of protein kinases, and play important roles in mediating cell proliferation, differentiation, survival and apoptosis