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PMCID: PMC8132533

The theoretical benefit compared to the peptides is reduced receptor desensitisation and a different tolerability profile, though whether that translates to clinically meaningful differences in nausea, vomiting and discontinuation rates is still under investigation

Although gastrointestinal adverse events (AEs), such as nausea, are more common in the 3 mg treatment group, other AEs such as hypoglycemic episodes and pancreatitis did not show dose dependency

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