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GIP mediates the incretin effect and glucose tolerance by dual actions on cells and cells

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Dehydration represents an important factor, as GLP-1 medications can cause nausea, vomiting, and diarrhea, particularly during dose escalation, leading to volume depletion

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Exenatide ameliorates intramyocellular lipid deposition through improving insulin sensitivity and activating the AMP-activated protein kinase (AMPK) signaling pathway without BW reduction [18]

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The most common include: Nausea (usually temporary and decreases over time) Gastrointestinal discomfort Constipation or diarrhea Fatigue in the initial weeks In my Miami practice, Ive found that starting with lower doses and gradually increasingalong with specific dietary recommendationssignificantly reduces these side effects

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This is what I tell my patients when they ask me which one is "better." The Short Answer Tirzepatide produces more weight loss on average

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