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Patients on Lillys tirzepatide achieved a greater likelihood of 5% to 15% or greater body weight, and also experienced more significant weight reductions at 3, 6, and 12 months in comparison to those on semaglutide

Moreover, how does it interact with alcohol

Your GP or diabetes care team will conduct a thorough risk-benefit assessment , taking into account your glycaemic control, overall health, breastfeeding goals, and any other medications you may be taking

Medications that delay gastric emptying may alter the speed and magnitude of GLP-1 effects

Pharmacodynamic Effects and Duration Despite measurable plasma clearance, pharmacodynamic effects extend well beyond plasma half-life[20]: Weight loss effects continue throughout treatment with no plateau observed within 48-week study periods Glycemic improvements persist between weekly doses with stable glucose control Appetite suppression effects remain consistent throughout dosing intervals Tissue receptor occupancy likely exceeds plasma peptide concentrations This disconnect between pharmacokinetics and pharmacodynamics suggests prolonged receptor engagement, tissue depot effects, or persistent downstream signaling cascade activation