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Efficacy In the original phase 3 randomized trials for obesity, average weight reduction compared to placebo has ranged from 5.3 % to 17.8 % after 5672 weeks (Table 1), with improvements in several obesity-related risks and complications [[13], [14], [15]]

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Some individuals may attempt to use doses lower than the licensed starting doses or remain at the initial dose indefinitely, rather than following the licensed escalation protocol

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