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Mice deficient for Irs2 [544], or transgenic mice deficient in CREB activity [546], are hyperglycemic due to severe -cell destruction and enhanced -cell apoptosis

This creates a feedback loop

Lancet Diabetes Endocrinol 2(10):801809 Li K, Zou J, Ye Z, Di J, Han X, Zhang H et al (2016) Effects of bariatric surgery on renal function in obese patients: a systematic review and meta analysis

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