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It has drawn growing research interest in experimental models exploring glucose-dependent pathway activity, energy balance, signaling efficiency, and behavioral response to nutrient exposure under sustained intake conditions

Excess weight interferes with hormone balance and ovulation

Several ongoing clinical trials are now evaluating: Biological aging biomarkers Physical function and frailty Vascular aging Cognitive outcomes Epigenetic aging Long-term healthspan endpoints As longevity physicians, we should remain enthusiasticbut scientifically disciplined

adults say they currently take a GLP-1 medication, up from 3% in 2024, and 15% report that they have used the drugs for weight loss at some point

Criminal counterfeiters are exploiting Americans demand for blockbuster diabetes and weight loss drugs made with semaglutide and tirzepatide, while compounders, telehealth companies, and med spas strain and skirt public health measures to meet high demand.