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While it has been postulated that these two actions are inextricably linked more recent data shows they can indeed be divorced which opens the opportunity for tailored pharmacology that provide food intake reduction without the adverse events typically associated with GLP-1R agonism

Risk of Hypoglycemia with Concomitant Use of Anti-Diabetic Therapy: When Saxenda is used with an insulin secretagogue (e.g., a sulfonylurea) serious hypoglycemia can occur

If dual agonists produce faster or more noticeable results, patients may maintain adherence better compared to slower-acting single agonists

Incretin-based drugs and the incidence of prostate cancer among patients with type 2 diabetes

Lthi H, Lengsfeld S, Burkard T, Meienberg A, Jeanloz N, Vukajlovic T, et al