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The hypothalamus can make GLP-1, as well as regions of the brain stem

If your doctor questions whether you've done enough with diet and exercise, don't become defensiveinstead, provide specific examples of calorie tracking, exercise frequency, and the timeline over which you've maintained these efforts without significant results

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It is not a clinical guideline but a conceptual structure for understanding how these factors interact

Ex-enatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial