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[DOI] [PubMed] [Google Scholar] 80.Blackman A, et al

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Activating GLP-1R suppresses exogenous lactate-induced NLRP3 inflammasome activation and histone lactylation in fibroblasts Extracellular acidosis has been reported to directly trigger or augment NLRP3 inflammasome activation [33, 34], and our results showed that the release of lactate was highly enhanced in activated fibroblasts