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The Bottom Line: By targeting two distinct hormone pathways instead of just one, Survodutide represents a powerful potential new tool in the expanding toolkit for chronic weight management and cardiometabolic health

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This research offers further insight into this emerging safety signal, according to the study authors who noted in their Ophthalmology paper, Our novel, stratified analysis provides a more nuanced interpretation than previous pooled reviews, isolating a potential increased risk signal to observational data in the diabetes population only, a finding not corroborated by RCTs. These results are somewhat at odds with the narrative surrounding GLP-1 use and NAION risk that began in early 2024, but the researchers say they are confident in their methodology

Separately, a spokesperson for FDA's Center for Drug Evaluation and Research , said it was possible compounded semaglutide is exempt from normal FDA approval if it is "made using a bulk drug substance (active ingredient) that is a component of an FDA-approved human drug product, provided all other conditions

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