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I don't get the stigma of saying people with PCOS shouldn't use it 'cause it's off-label

Additionally, visual aids and simple analogies can enhance understanding

Oral formulations have a shorter half-life.[ref] In clinical trials, GLP-1 RAs improved lipid profiles, increased satiety, slowed gastric emptying, reduced inflammation, and had neuroprotective effects.[ref] The slowing of gastric emptying and reducing inflammation may play a role in weight loss, along with the decrease in appetite and eating less

In a 12-week preliminary RCT, patients with obesity on GLP-1RA following a diet consisting of 1.3 g/kg protein successfully promoted fat mass reduction while preserving fat free mass, muscle strength, and resting metabolic rate compared to those following a traditional isocaloric diet [57]

[11] [12] While this may seem small, even modest reductions in blood pressure can translate into meaningful decreases in cardiovascular events at a population level