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Current and pipeline incretin portfolio: GLP1, GLP1/GIP, GLP1/GRA, and amylincontaining combinations across SC and oral routes, with several Phase 23 agents aiming for ~2025% weight loss and cardiometabolic indications.

Longitudinal Targeted Minimum Loss-based Estimation, a method that adjusts for both baseline and time-varying confounding, was used to estimate absolute risks of cardiovascular outcomes under sustained use of GLP1-RA and DPP 4i (active comparator), adjusting for baseline and time-varying confounding

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