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At present, tirzepatide in T1D should be regarded as an emerging investigational strategy rather than an established therapy

Common adverse effects include gastrointestinal symptoms such as nausea (12-29% of patients), diarrhea (12-16%), vomiting (6-9%), and constipation (6-11%), with rates varying by dose

Patients were randomized in a 1:1:1 ratio to once weekly fixed dosage of ZEPBOUND 10 mg, ZEPBOUND 15 mg, or placebo with an escalation period of up to 20 weeks followed by the maintenance period

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The screening process is designed to identify the conditions that make tirzepatide unsafe before any prescription is issued