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Description
You can read the abstract of this article at In the SURPASS-4 trial, the dual GIP and GLP-1 receptor agonist tirzepatide demonstrated superior reductions in HbA1c concentrations, bodyweight, and blood pressure compared to titrated daily insulin glargine in individuals with type 2 diabetes and cardiovascular risk

Serious allergic reactions, serious infections, and new or worsening inflammatory bowel disease symptoms require prompt medical attention

Rather than targeting GLP-1 receptors alone, it's a dual agonist activating both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously

158 In addition, the C max and AUC of furosemide were decreased by 34% and increased by 28%, respectively

Conversely, the addition of a SGLT2i to GLP-1RA treatment showed only an increased incidence of genital infections
