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Rotate between 4 quadrants each week: right upper, left upper, left lower, right lower
Because fiber slows digestion and helps regulate glucose absorption, it naturally stimulates GLP-1 secretion in the gut

Others, including some antidepressants and antidiabetic agents, may enhance metformin's blood sugar-lowering effect, which can raise the risk of hypoglycemia

In VNS trials, ensuring a proper placebo control group is difficult because the participants can feel the stimulation effects of the VNS devices, which dont provide true blinding