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The metabolic clearance occurs by proteolytic cleavage of the tirzepatide peptide backbone, -oxidation of the C20 fatty diacid moiety, and by amide hydrolysis

Hair loss associated with tirzepatide treatment is most commonly attributed to telogen effluvium , a form of temporary hair shedding triggered by physiological stress rather than a direct pharmacological effect of the medication itself

The infant's gastrointestinal tract would likely break down tirzepatide before significant absorption could occur
