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Initially developed for diabetes, they are now widely used for obesity treatment and are under investigation for a wide range of other conditions, from kidney and heart disease to addiction to dementia

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Approval of new medications will introduce competition and may lower unit cost

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Some medicines used for weight management act on GLP-1 alone, while others act on more than one metabolic pathway

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These agents have also demonstrated additional metabolic benefits such as delayed gastric emptying and reduced appetite, which contribute to improved overall glycaemic outcomes and cardiometabolic health 7

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95% CI, 0.48-0.82), SGLT2i (HR, 0.68

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