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Health Canada has not provided specific approval dates for individual applications currently under review

Survodutide (BI 456906) was evaluated in two phase I studies involving healthy volunteers and individuals with overweight/obesity

This resistance can arise from a weak immune response within the tumor, reduced surface MHC expression, and dysfunctional interferon-gamma (IFN-) signaling, all of which contribute to a cold tumor microenvironment (TME) characterized by limited T cell presence

Those with severe gastroparesis or other gastrointestinal disorders may not tolerate the GI effects well, even with the potentially improved profile compared to Semaglutide

[DOI] [PMC free article] [PubMed] [Google Scholar] [221].Deryabina MA, Daugaard JR, Knudsen CB, Shelton PT, Fog JU, Jessen L, Noerregaard P, Pharmacokinetics and Pharmacodynamics of GLP-1-GIP Receptor Dual Agonist Peptides: From Once-Daily to Once-Weekly, Diabetes, 64 (2015) A534A534