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The Hallmarks of Aging: A Framework for Understanding Biological Aging In 2013, Lpez-Otn and colleagues introduced the Hallmarks of Aging framework, which was a conceptual model that organized decades of aging research into nine core biological processes that contribute to age-related decline [2]

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Obesity-related comorbidities such as cardiovascular disease: as obesity and metabolic dysfunction worsen, effects of GIP/dual incretin therapies may address risk factors

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Stapled and xenopus glucagon-like peptide 1 (GLP-1)-based dual GLP-1/gastrin receptor agonists with improved metabolic benefits in rodent models of obesity and diabetes