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Description
Since its introduction, there has been ongoing discussion within the medical community regarding a potential association between GLP-1 receptor agonists and acute pancreatitis

Participants with prediabetes who took semaglutide also saw significant improvements in HbA1c, fasting glucose, and body weight compared to placebo

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This dual-agonism activity of tirzepatide may contribute to the greater weight reduction observed with tirzepatide than with semaglutide, a monoagonist used in the current trial. The results show that as weight reduction increased there were greater improvements in cardiometabolic risk factors, including blood pressure, and blood fat and sugar levels, with both treatments consistent with previous reports

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