only losing 1 pound a week on semaglutide Weight Loss: Results & Your Guide I Lost 35lbs in 3
Description
There are relatively few prospective studies on the combined use of GLP-1RAs and SGLT2is, although a meta-analysis has suggested a benefit of the combination in terms of improved reductions in HbA 1c and body weight [37]

For patients who are tolerating the maximal therapeutic dose of a once-daily or twice-daily GLP-1 receptor agonist (exenatide 10 g twice daily, liraglutide 1.8 mg once daily, or lixisenatide 20 mg once daily) but who are changing to a once-weekly GLP-1 receptor agonist, we recommend starting dulaglutide once weekly or exenatide once weekly at the maximal therapeutic dose (dulaglutide 1.5 mg, exenatide 2 mg)

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doi: 10.1001/jama.2019.2942

Those with moderate to severe non-proliferative diabetic retinopathy or proliferative disease at baseline may experience progression, particularly during the initial months of treatment when glycaemic control improves rapidly