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Indian J Exp Biol

Taken together, these pooled safety analyses (119123) and CV outcome safety trials (124127), together with review of published data from numerous clinical trials (39), provide reassuring evidence that the catalytic activity of the DPP-4 molecule can be modulated to enhance the beneficial metabolic effects of its substrates (such as the incretin hormones) without adversely affecting any of the protease-independent metabolic effects discussed above, or interfering with any of its other (non-metabolic) functions

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The average score was 5.4, with similar numbers of respondents on each side of the scale