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This change in food intake is largely mediated by estradiol, which acts directly upon anorexigenic and orexigenic neurons, largely in the hypothalamus

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Further, alpha-MSH acts on melanocortin 4 receptors (MC4R) in the paraventricular nucleus in the hypothalamus, leading to a decrease in appetite [17]

"He hit me with the, 'I'm almost grown,'" says Kim