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Obesity in PCOS women exacerbates these metabolic disturbances and aggravates its symptoms

Mutagenesis The molecular determinants of GLP-1R ligand binding and functionality have been investigated extensively using truncated, chimeric, and site-specifically substituted GLP-1, exendin-4, and peptide ligands of closely related class B GPCRs (including glucagon and GIP)

Natalie Pollock is a senior at UNC-Chapel Hill studying media and journalism with a minor in conflict management

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A few months later, in January 1987 the group reported that the porcine peptide stimulated a small increase of insulin secretion from an isolated perfused pig pancreas and that they had observed a similar effect with a synthetic replica of the natural hormone