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Pre-treatment with a GLP1 receptor-blocking antibody neutralised the CNO-dependent improvement in glucose tolerance but did not affect the reduction in food intake, and an independent group of animals pair-fed to the CNO-treatment group demonstrated attenuated weight loss
The percentage of body weight reduction was 19.74.1% for semaglutide, 31.67.6% for tirzepatide, and 24.15.8% for retatrutide

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