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Hyperinsulinemia resulting from insulin resistance stimulates excessive androgen production by the ovaries and adrenal glands, exacerbating hyperandrogenemia and ovulatory dysfunction ( e.g ., diet and exercise) and pharmacological treatments ( e.g ., metformin, GLP-1 receptor agonists) can ameliorate insulin resistance and improve metabolic outcomes in PCOS ( 2.3 Hormonal imbalance Hyperandrogenemia is a defining feature of PCOS, characterized by elevated serum testosterone, androstenedione, and dehydroepiandrosterone (DHEA) levels, leading to clinical manifestations such as hirsutism, acne, and alopecia

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The aim of this study was to confirm previous findings on the effect of allulose in mitigating some of the metabolic effects of a Western diet and add to this by including outcomes specific to adipose physiology and mitochondrial bioenergetics

On this page, we will discuss tirzepatide from the viewpoint of its use for chronic weight management in adults

Turner RC, Cull CA, Frighi V, et al