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It has been FDA approved since 1959, mainly for short-term use
Semaglutide was approved in 2017 as Ozempic for diabetes, and in 2021 as Wegovy for obesity
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Patients starting both medications simultaneously face a higher risk of either insufficient glucose control or unexpected hypoglycemic episodes if dosing is not carefully adjusted
A reduction in bile acid absorption has been suggested as a mechanism through which chronic metformin treatment can lower cholesterol [72, 73]
