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[28] [9] Close collaboration between gastroenterology and endocrinology or diabetes specialists is advisable

While GLP-1 agonists don't require specific dietary patterns, emphasizing whole foods, adequate protein (generally 0.8-1.2 g/kg body weight, with higher amounts individualized based on health status), and fiber (25-35 g daily) enhances satiety

Clinical trial data shows weight regain typically begins within 6 to 12 months of complete discontinuation, supporting ongoing maintenance rather than stopping entirely

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Cardiometabolic benefits Both tirzepatide and retatrutide have demonstrated improvements in various cardiometabolic risk factors, such as blood pressure, lipid profiles, and glycemic control