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Tirzepatide is typically initiated at 2.5 mg weekly and gradually increased at minimum 4-week intervals through 5 mg, 7.5 mg, 10 mg, 12.5 mg to a maximum of 15 mg based on individual response and tolerability

Weeks 11 through 16 (standard therapeutic doses, 2.5 to 5.0 mg): Weight loss accelerates to rates consistent with clinical trial data

If you inject Sunday evening Eastern Time and then fly to the West Coast, your "Sunday evening" is 3 hours different

The GIP component appears to provide metabolic advantages beyond what GLP-1 offers alone

Switching to oral with variable absorption means those blood levels become unpredictable