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The study found that while participants lost an average of 14.9% of their body weight, approximately 40% of the mass lost was lean mass (Wilding et al., 2021)

Wegovy (semaglutide injection): This is a once-weekly injectable prescribed for weight loss

Back Sheridan, C (14 April 2025) 'Not just obesity: GLP-1 receptor agonists advance on addiction', Nature Biotechnology , 43, 455-47.Back Sims, EK, Carr, ALJ, Oram, RA, et al (15 July 2022) '100 years of insulin: celebrating the past, present and future of diabetes therapy', Nature Medicine , 27/7, 1154-64

Retatrutide acts via cell-surface incretin and glucagon receptors, whilst 5-Amino-1MQ works intracellularly by modulating enzyme activity and NAD+ metabolism