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Clinical studies with liraglutide, for example, demonstrated enhanced hepatic insulin sensitivity, with suppression of endogenous glucose production by 9.36% under low-dose insulin infusion compared with 2.54% in placebo-treated controls

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In clinical trials, semaglutide has been found to be associated with significant weight loss when compared to placebo

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8 The investigators concluded that early worsening of diabetic retinopathy is a previously known phenomenon associated with rapid and large improvements in glycaemic control with insulin, and the findings in SUSTAIN-6 were consistent with this