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6 Additionally, insulin resistance may lead to dopamine degeneration and disrupted glucose metabolism in several brain regions, further exacerbating the progression of PD

Zabihi said this is an option for customers who want to shed pounds at a slower rate without taking a GLP-1 drug

As of early 2025, well over 30 new GLP-1 drugs are in development

3.1.2 Exenatide As the first GLP-1R agonist approved for T2DM, EX is a new class of compound and a synthetic product of exendin-4, which is a compound naturally derived from the Gila monster and has multiple hypoglycemic mechanisms: inhibiting of glucagon release from cells, slowing of gastric emptying, decreasing appetite and increasing glucose-dependent insulin secretion (12, 46, 47)

A study presented recently at ARVO 2026 analyzed the incidence of glaucoma, macular and ophthalmic diseases over a four-year period among non-diabetic adults prescribed GLP-1 drugs and found these medications provide a variety of protective signals