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Diabetes Care 24:489494 Green BD, Irwin N, Duffy NA, Gault VA, OHarte FP, Flatt PR (2006) Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1

While both are highly effective, they have key differences in how they work, their effectiveness, and their side effect profiles

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The likely reason, she explained, is that these drugs act on the same reward circuitry that drives food cravings, so when those circuits become less reactive, other urges can ease, too