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Starting Dose and Gradual Dose Adjustment Management is typically initiated at a lower dose and gradually increased to minimise gastrointestinal side effects and improve tolerability, as directed by the doctor

Next-generation therapies for DKD that are currently in development include various incretin-based therapies, endothelin receptor antagonists, aldosterone synthase inhibitors, soluble guanylate cyclase agonists and anti-inflammatory agents
This year, all variables are imputed following a hotdeck approach

However, it significantly affects metabolic markers

doi: 10.1038/ijo.2016.52 3 DaviesMJBergenstalRBodeBKushnerRFLewinASkjthTVet al
