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The hypothesis posits that a systems-based review of GLP-1 RA mechanisms will reveal positive and negative effects across multiple organ systems, providing comprehensive insights into the hormone's physiological impact.This systematic review will assess the appropriateness of GLP-1 RAs in various aforementioned patient health states, shedding light on their potential impacts on comorbidities

It is typically used alongside a healthy diet and exercise program to help manage diabetes

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Tirzepatide was found to improve insulin sensitivity and insulin secretory responses to a greater extent than semaglutide, and this was associated with lower prandial insulin and glucagon concentrations