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Additionally, GLP-1 receptors have been found in neurons, and in the brain [11]

In an in vivo study, the acute treatment with GLP-1 in female rats resulted in the increase of the amplitude of the preovulatory LH surge, likely by the activation of the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons [35]
There is an ongoing study to confirm the clinical benefit of Wegovy in adults with MASH

Regulatory harmonization further facilitates commercial viability