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This peculiarity is not shared by LPI species with different aliphatic chains, which have been described as the ligands of GPR55 (317)

These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [1922], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]

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It was found that GLP-1 when bound to GLP-1R (Figure 1), can increase the concentration of cAMP by activating adenylate cyclase (AC) and stimulating the conversion of ATP to cyclic adenosine monophosphate (cAMP)