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Further LEfSe analysis showed that Lactobacillus and Bifidobacterium played an essential role in regulating intestinal microbiota diversity

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Your healthcare provider may wish to perform blood tests to exclude other causes of cold intolerance, such as: Thyroid function tests (TSH, free T4) to rule out hypothyroidism Full blood count to check for anaemia Ferritin and iron studies , particularly if anaemia is suspected Vitamin B12 and folate levels , particularly if you have a history of metformin use (MHRA has issued a Drug Safety Update on metformin and B12 deficiency) HbA1c to assess diabetes control It is important not to discontinue Ozempic without medical advice, as abrupt cessation may lead to deterioration in glycaemic control