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[5] Unknown Long-Term Consequences The most significant concern is that Ozempic overall is still a relatively new drug, particularly in the context of long-term, non-diabetic use for weight management

Further, GLP-1RAs block the adhesion of monocytes to endothelium induced by oxidized LDL via extracellular signal-regulated kinase (ERK) 5-Kruppel-like factor (KLF)2 signaling pathway to prevent endothelial permeability [107, 108]

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: A meta-analysis

Glucagon-like peptide-1 receptor agonists and risk for gastroesophageal reflux disease in patients with type 2 diabetes : a population-based cohort study

For example, one patient who used a compounded GLP-1 drug developed severe kidney problems, leading to hospitalization