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Dula also significantly reduced the expression of transforming growth factor-1 (TGF-1), phosphatidylinositol-3-kinase (PI3K), protein kinase B (AKT) signaling pathway, and the inflammatory cytokines: nuclear factor kappa B (NF-B), interleukin-6 (IL-6), and interferon- (IFN-) in colonic cellular structures

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People with alcohol use disorder and obesity drank less when treated with a GLP-1 drug in addition to cognitive behavioral therapy.

While prescription versions can amplify its effects, physicians say diet, movement and metabolic health still shape how well GLP-1 works naturally.