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Patients who use semaglutide as a pharmacologic bridge to establish new behavioral patterns, improve metabolic health, and reduce fat mass can sometimes transition to lower doses or off medication with sustained results, particularly when the foundational hormonal and metabolic picture has been optimized

Many find satisfactory results at 4-8mg weekly, significantly reducing both cost and vial requirements

Consider protein shakes if whole food intake is difficult nutrition during peptide therapy

This is referred to as metabolic adaptation, which reduces GLP-1 and GIP levels and increases the orexigenic hormone ghrelin

10.4093/dmj.2019.0018 Diabetes Metab