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If you want a clearer look at how semaglutide can affect blood pressure, read Managing Blood Pressure While on Semaglutide for Weight Loss

5.2 Primary Pulmonary Hypertension Primary Pulmonary Hypertension (PPH) a rare, frequently fatal disease of the lungs has been reported to occur in patients receiving a combination of phentermine with fenfluramine or dexfenfluramine

B12 injections are generally very safe with minimal side effects

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One possible explanation is that semaglutide stays in the body longer, which means it can provide a more sustained effect on GLP-1 receptors, including those in the brain that affect dopamine